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Symptoms typically appear in early childhood, though diagnosis can occur later, especially in milder cases

It adds surface trauma to already-inflamed tissue, increases the risk of rupture and scarring, and can spread bacteria to adjacent follicles

However, it is plausible that the heightened risk of neurodegeneration associated with ranibizumab may primarily affect individuals already predisposed to such side effects due to underlying factors like a family history of PD or AD, or the presence of uncompensated diabetes (Sultana and Scondotto 2020

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For patients who have been living with chronic injury pain, this reduction feels transformative